Rejuran Healer in Korea is the base polynucleotide (PN) injectable from Pharma Research, and it suits people whose main concern is skin quality: dullness, fine lines, rough texture, or skin that feels thin and slow to recover. It holds PN in a water-based solution of about 20 mg per mL, without the hyaluronic acid and lidocaine added to HB Plus or the eye-area design of Rejuran i. A full-face session places the product at roughly 200 to 300 points after numbing cream. Raised bumps for one to three days are expected, and bruising or redness can follow. Changes build over a course, effects commonly last four to six months, and results vary from person to person.
Guide
Where Healer sits in the Rejuran range
Pharma Research sells several PN products under one brand name. Healer is the starting formula; later lines keep the PN base and change one element. HB Plus adds hyaluronic acid for moisture and lidocaine to soften the sting, and Rejuran i is prepared for the thin skin around the eyes.
Clinics often use two lines in one visit, so a plan that simply says Rejuran is incomplete; the line should be written next to each zone.
| Line | What changes from Healer | Typical reason it is chosen |
|---|---|---|
| Rejuran Healer | Baseline: PN only, water-based | Overall skin quality across the face |
| Rejuran HB Plus | Adds hyaluronic acid and lidocaine | Dry skin, or low tolerance for injection discomfort |
| Rejuran i | PN prepared for very thin skin | Fine lines and crepiness around the eyes |
Guide
Skin and goals that line up with Healer
Healer tends to fit people who want the skin itself to look and feel healthier rather than fuller: texture that has turned rough, fine lines across the cheeks, thin or reactive skin, or skin that stays red and touchy after repeated lasers. With no hyaluronic acid in the syringe, it is often picked when repair and resilience matter more than a quick glow, and when gradual change is preferred over a visible top-up.
It is a weaker match for deep folds, hollow temples or sagging jowls, which need a filler, a collagen-stimulating booster or a lifting device.
Guide
Who should wait or pick a different option
People who are pregnant or breastfeeding, or who have an active infection, cold sore, acne flare or eczema on the face, should postpone treatment. The PN in Healer is purified from fish DNA, so a fish or salmon allergy must be raised first. Blood thinners make bruising more likely, and an autoimmune condition or past reaction to injectables needs a doctor's review.
Expected effects are small bumps at each point that flatten within one to three days, redness, stinging during injection, mild swelling and bruising. Less often, lumps that last longer, infection at a needle point or an allergic reaction occur.
Guide
How a Healer course is usually planned
Healer is rarely a single-visit treatment. The doctor sets the number of sessions and their spacing from your skin and from how often you can return. Cavallini and colleagues, in a 2021 consensus report in the Journal of Cosmetic Dermatology, gave area-by-area guidance for highly purified polynucleotide products on technique, injected volume, number of sessions and the interval between them, covering the face, eye area, neck, hands and scalp.
That report concerned a different PN product family, not Rejuran, but it shows this class is planned as a course. Visitors often begin on one trip and continue later, so keep the line name, amount per area and date of each session in writing for the next doctor.
Guide
What the evidence on PN shows so far
Lampridou and colleagues reviewed the research systematically in the Journal of Cosmetic Dermatology in 2024. They found nine studies of low to moderate quality covering 219 patients treated with polynucleotides. Injections were linked with fewer wrinkles, smoother texture and better elasticity, with statistically significant results in several studies, and side effects were generally mild and short-lived.
The authors noted wide variation in injection areas and technique and limited agreement on optimal use, and called for larger, better-designed trials. That frames Healer fairly: a well-tolerated option for skin quality with promising but limited evidence, not a substitute for volume or lifting treatments.
Evidence
Research behind this page
- The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic ReviewJournal of Cosmetic Dermatology · 2024 · doi:10.1111/jocd.16721
A systematic review of nine low- to moderate-quality studies with 219 patients, linking PN injections to fewer wrinkles and better texture and elasticity, with mostly mild side effects.
- Consensus report on the use of PN‐HPT™ (polynucleotides highly purified technology) in aesthetic medicineJournal of Cosmetic Dermatology · 2021 · doi:10.1111/jocd.13679
An expert consensus on technique, dosage, volume, session number and intervals for highly purified polynucleotides across face and body.
FAQ
Questions about Skin boosters in Gangnam
How can I confirm the syringe is Healer and not another Rejuran line?
Ask to see the sealed box before treatment, with the product name, maker, lot number and expiry date printed on it. Healer, HB Plus and i come in separately labeled packaging, so the line is easy to read once the box is in front of you. Keep a note of the line and lot for any later follow-up. Ask which line goes on each area.
Can Healer and Rejuran i be used in the same session?
Yes, combining them in one visit is common, with Healer on the cheeks and forehead and the i line under the eyes. The doctor chooses by skin thickness in each zone rather than using one product everywhere. Recovery is similar for both, with small bumps for a few days. Make sure the plan names which line and how much product goes on each area before numbing starts.
Does Rejuran Healer in Seoul sting more than HB Plus?
It can feel sharper, because Healer has no lidocaine inside the product while HB Plus does. Clinics use numbing cream before injection either way, and many people describe a brief stinging at each point. Tolerance differs a lot between people and areas, with the upper lip and forehead often more sensitive. If comfort is a concern, ask the doctor whether HB Plus suits your skin goal as well.
How soon after Healer can I go sightseeing or take a flight?
Most people walk out and continue their day, although the bumps are visible for one to three days. Avoid saunas, hard workouts and alcohol on the treatment day to limit swelling and bruising. A flight is usually fine once the needle points have closed, but ask the doctor about your own timing. Plan photos and events a few days after the session rather than the next morning.
Can Healer be given on the same day as a laser?
Some clinics do pair the two in one visit, usually laser first and injections afterward, but the doctor decides by skin condition. Combining them can raise redness and swelling for a few days, and very sensitive skin may do better with separate days. Ask which order is planned and what aftercare covers both. Check the combined recovery time as well.
Which skincare should I pause around a Healer visit?
Pause retinoids, strong acids and scrubs for a few days before and after injection, unless the doctor advises otherwise. These can make punctured skin sting and stay red longer. Gentle cleansing, a plain moisturizer and sunscreen are usually enough at first. Bring a list of your current products to the consultation. The doctor can then tell you when to restart.